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货号： bs-11808R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11808R-Bio
- 英文名称
- Anti-BHLHB5/Biotin
- 中文名称
- 生物素标记的螺旋一环一螺旋蛋白5抗体
- 别 名
- BETA 3; Basic helix loop helix protein 5; Beta3; BHE22_HUMAN; bHLHB5; bHLHe22; CAGL85; Class B basic helix-loop-helix protein 5; Class E basic helix-loop-helix protein 22; Class II bHLH protein BHLHB5; TNRC20; Trinucleotide repeat containing 20; Trinucleotide repeat-containing gene 20 protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 37kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BHLHB5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes. Class A proteins include the ubiquitously expressed E-box binding factors E12/E47, ITF2 and HEB (BETA 1 or HTF4). Class B proteins such as Myo D, myogenin and Neuro D (BETA 2) are transiently expressed and exhibit a more limited tissue distribution. Class A proteins heterodimerize with class B proteins to activate transcription. Working in opposition to these positively acting factors are a specialized group of proteins that function as dominant negative regulators. For instance, the Id family of transcriptional repressors contains a HLH region required for dimerization but lacks a functional DNA-binding domain. The Id family can therefore form heterodimers with the myogenic family, but the resulting complexes are transcriptionally inactive. BETA 3 is a protein that is functionally similar to members of the Id family in that it can inhibit the binding of E47 homodimers as well as E47/Neuro D and E47/Myo D heterodimers to consensus DNA sequences . In contrast to members of the Id family, BETA 3 contains a putative DNA-binding domain.
Function:
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA.
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain-specific, with the highest expression in the cerebellum.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Database links:Entrez Gene: 27319Human
Entrez Gene: 59058Mouse
Entrez Gene: 365748Rat
Omim: 613483Human
SwissProt: Q8NFJ8Human
SwissProt: Q8C6A8Mouse
Unigene: 388788Human
Unigene: 591870Human
Unigene: 149938Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.