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货号： bs-20185R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20185R-AF594
- 英文名称
- Anti-POFUT1/AF594
- 中文名称
- AF594标记的蛋白O岩藻糖基转移酶1抗体
- 别 名
- FUT 12; FUT12; GDP fucose protein O fucosyltransferase 1; GDP-fucose protein O-fucosyltransferase 1; O Fuc T; o fucosyltransferase protein; O FucT 1; O FucT; O FucT1; O FUT; O-FucT-1; OFUT 1; OFUT; OFUT1; OFUT1_HUMAN; Peptide O fucosyltransferase1; Peptide-O-fucosyltransferase 1; Pofut 1; POFUT1; Protein O fucosyltransferase1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 干细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 41kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human POFUT1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Glycosyltransferases that mediate the regio- and stereoselective transfer of sugars, such as the fucosyltransferases, determine cell surface-carbohydrate profiles, which is an essential interface for biological recognition processes. Fucosyltransferases catalyze the covalent association of fucose to different positional linkages in sugar acceptor molecules. POFUT1 (protein O-fucosyltransferase 1), also known as FUT12, O-FUT or O-FucT-1, is a 388 amino acid protein that localizes to the endoplasmic reticulum and belongs to the fucosyltransferase subfamily of glycosyltransferases. Highly expressed in pancreas, kidney, lung, heart, brain, liver, placenta and skeletal muscle, POFUT1 uses manganese to catalyze the attachment (specifically the O-glycosidic linkage) of fucose to a conserved serine or threonine residue on a protein acceptor. Via its cataytic activity, POFUT1 plays an important role in Notch signaling, as Notch ligands can serve as POFUT1 substrates. Two isoforms of POFUT1 exist due to alternative splicing events.
Function:
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling.
Subcellular Location:
Endoplasmic reticulum.
Tissue Specificity:
Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the glycosyltransferase 68 family.
Database links:Entrez Gene: 23509Human
Entrez Gene: 140484Mouse
Entrez Gene: 311551Rat
Omim: 607491Human
SwissProt: Q9H488Human
SwissProt: Q91ZW2Mouse
SwissProt: Q6EV70Rat
Unigene: 472409Human
Unigene: 293761Mouse
Unigene: 214685Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.