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货号： bs-6324R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6324R-AF594
- 英文名称
- Anti-Desmocollin 1 + 2/AF594
- 中文名称
- AF594标记的桥粒糖蛋白1/2抗体
- 别 名
- Cadherin family member 1; CDHF1; Desmocollin1; Desmosomal glycoprotein 2/3; DG2/DG3; DSC 1; DSC1; DSC1_HUMAN; DSC2_HUMAN; ARVD11 antibodyCadherin family member 2; CDHF2; Desmocollin-2; Desmocollin2; Desmosomal glycoprotein II; Desmosomal glycoprotein II/III; DG2; DSC 2; DSC2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 84kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Desmocollin 1 + 2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Function:
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Subunit:
.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Tissue Specificity:
Strongly expressed in epidermis, less in lymph node and tongue.
Similarity:
Contains 5 cadherin domains.
Database links:Entrez Gene: 1823 Human
Entrez Gene: 13505 Mouse
Entrez Gene: 291759 Rat
Omim: 125643 Human
SwissProt: Q08554 Human
SwissProt: P55849 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.