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货号： bs-20263R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20263R-AF594
- 英文名称
- Anti-Pescadillo/AF594
- 中文名称
- AF594标记的Pescadillo抗体
- 别 名
- FLJ43790; Homo sapiens pescadillo mRNA complete cds; PES 1; PES; pes1; PESC_HUMAN; Pescadillo (zebrafish) homolog 1 containing BRCT domain; Pescadillo homolog 1; Pescadillo homolog 1 containing BRCT domain (zebrafish); Pescadillo homolog; Pescadillo ribosomal biogenesis factor 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Pescadillo
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Pescadillo may play a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression. The protein is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product.
Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subunit:
Interacts with IRS1 and UBTF. May interact with MAP1B (By similarity). Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
Subcellular Location:
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.
Tissue Specificity:
Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
Post-translational modifications:
Sumoylated.
Similarity:
Belongs to the pescadillo family.
Contains 1 BRCT domain.
Database links:Entrez Gene: 23481 Human
Entrez Gene: 64934 Mouse
Entrez Gene: 289740 Rat
Omim: 605819 Human
SwissProt: O00541 Human
SwissProt: Q5SQ20 Mouse
SwissProt: Q9EQ61 Mouse
SwissProt: Q3B8N8 Rat
Unigene: 517543 Human
Unigene: 28659 Mouse
Unigene: 9521 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.