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货号： bs-4435R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4435R-AF594
- 英文名称
- Anti-PURB/AF594
- 中文名称
- AF594标记的转录激活蛋白PURB抗体
- 别 名
- Pur beta; purB; PURB_HUMAN; PURBETA; Purine rich element binding protein B; Purine-rich element-binding protein B; transcriptional activator protein Pur beta; Transcriptional activator protein Pur-beta.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 33kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PURB
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Function:
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs.
Subunit:
Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in myocardium of heart failure patients.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the PUR DNA-binding protein family.
Database links:Entrez Gene: 5814Human
Entrez Gene: 19291Mouse
Entrez Gene: 498407Rat
Omim: 608887Human
SwissProt: Q96QR8Human
SwissProt: O35295Mouse
SwissProt: Q68A21Rat
Unigene: 349150Human
Unigene: 596321Human
Unigene: 728785Human
Unigene: 296150Mouse
Unigene: 390332Mouse
Unigene: 156213Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.