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货号： bs-21124R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-21124R-AF594
- 英文名称
- Anti-RAXL1/AF594
- 中文名称
- AF594标记的视网膜前神经折叠同源框蛋白抗体
- 别 名
- ARMD6; CORD11; Macular degeneration, age related 6, included; MGC15631; Q50 type retinal homeobox; Q50-type retinal homeobox protein; QRX; rax2; RAX2_HUMAN; RAXL1; Retina and anterior neural fold homeobox like 1; Retina and anterior neural fold homeobox protein 2; Retina and anterior neural fold homeobox-like protein 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Chimpanzee,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RAXL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a homeodomain-containing protein that plays a role in eye development. Mutation of this gene causes age-related macular degeneration type 6, an eye disorder resulting in accumulations of protein and lipid beneath the retinal pigment epithelium and within the Bruchs membrane. Defects in this gene can also cause cone-rod dystrophy type 11, a disease characterized by the initial degeneration of cone photoreceptor cells and resulting in loss of color vision and visual acuity, followed by the degeneration of rod photoreceptor cells, which progresses to night blindness and the loss of peripheral vision. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Function:
May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.
Subcellular Location:
Nucleus.
DISEASE:
Defects in RAX2 are the cause of age-related macular degeneration type 6 (ARMD6) [MIM:613757]. ARMD is in most patients manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruchs membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders.Defects in RAX2 are the cause of cone-rod dystrophy type 11 (CORD11)
[MIM:610381]. CORD is characterized by the initial degeneration of cone photoreceptor cells, thus causing early loss of visual acuity and color vision, followed by the degeneration of rod photoreceptor cells and leading to progressive night blindness and peripheral visual field loss.
Similarity:
Contains 1 homeobox DNA-binding domain.
Database links:Entrez Gene: 84839Human
Omim: 610362Human
SwissProt: Q96IS3Human
Unigene: 532691Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.