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货号： bs-21129R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-21129R-AF594
- 英文名称
- Anti-OBSCN/AF594
- 中文名称
- AF594标记的遮蔽蛋白肌球蛋白轻链激酶抗体
- 别 名
- BC046431; Gm878; KIAA1556; KIAA1639; OBSCN; OBSCN_HUMAN; Obscurin; Obscurin-MLCK; Obscurin-myosin light chain kinase; Obscurin-RhoGEF; OTTMUSG00000005786; UNC89.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 868kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human OBSCN
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Function:
Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
Subcellular Location:
Cytoplasm > myofibril > sarcomere > M line. Cytoplasm > myofibril > sarcomere > Z line. In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells.
Similarity:
Belongs to the protein kinase superfamily.
CAMK Ser/Thr protein kinase family.
Contains 1 DH (DBL-homology) domain.
Contains 3 fibronectin type-III domains.
Contains 55 Ig-like (immunoglobulin-like) domains.
Contains 1 IQ domain.
Contains 2 PH domains.
Contains 2 protein kinase domains.
Contains 1 SH3 domain.
Database links:Entrez Gene: 84033Human
Omim: 608616Human
SwissProt: Q5VST9Human
Unigene: 650039Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.