产品中心
当前位置：首页>产品中心Anti-SLC24A1/AF594
货号： bs-21216R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-21216R-AF594
- 英文名称
- Anti-SLC24A1/AF594
- 中文名称
- AF594标记的溶质载体家族24成员1抗体
- 别 名
- CSNB1D; HsT17412; KIAA0702; Na(+)/K(+)/Ca(2+) exchange protein 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; NCKX; NCKX1; NCKX1_HUMAN; Retinal rod Na Ca+K exchanger; Retinal rod Na+/Ca+/K+ exchanger; Retinal rod Na-Ca+K exchanger; RODX; Slc24a1; Sodium/potassium/calcium exchanger 1; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1; Solute carrier family 24 member 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 121kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SLC24A1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Function:
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
Post-translational modifications:
The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.
DISEASE:
Defects in SLC24A1 are the cause of congenital stationary night blindness type 1D (CSNB1D) [MIM:613830]. An autosomal recessive form of congenital stationary night blindness a non-progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus.
Similarity:
Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
Database links:Entrez Gene: 9187Human
Entrez Gene: 56814Rat
Omim: 603617Human
SwissProt: O60721Human
SwissProt: Q9QZM6Rat
Unigene: 173092Human
Unigene: 205732Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.