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货号： bs-20303R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20303R-AF594
- 英文名称
- Anti-HAP1/AF594
- 中文名称
- AF594标记的舞蹈症相关蛋白1抗体
- 别 名
- Huntingtin Associated Protein 1; HAP 1; HAP 2; HAP-1; Hap1; HAP1_HUMAN; HAP2; HAPP; hHAP1; hHLP1; HIP 5; HIP5; HLP; HLP1; Huntingtin-associated protein 1; huntingtin-associated protein 2; Neuroan 1; Neuroan1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 75kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HAP1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Huntingtin-associated protein 1 binds to Huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of Huntingtin that leads to Huntington’s disease (HD). The ability of HAP1 to bind to Huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with Huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. HAP1 in rat has been shown to associate with a number of intracellular organelles. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons.
Function:
Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat.
Tissue Specificity:
Predominantly expressed in brain. Selectively expressed in neurons.
Similarity:
Contains 1 HAP1 N-terminal domain.
Database links:Entrez Gene: 9001 Human
Entrez Gene: 15114 Mouse
Entrez Gene: 29430 Rat
Omim: 600947 Human
SwissProt: P54257 Human
SwissProt: O35668 Mouse
SwissProt: P54256 Rat
Unigene: 158300 Human
Unigene: 281700 Mouse
Unigene: 37430 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.