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货号： bs-20575R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20575R-AF594
- 英文名称
- Anti-Syntaxin-1B/AF594
- 中文名称
- AF594标记的突触融合蛋白1B抗体
- 别 名
- STX1B_HUMAN; Syntaxin 1B; Syntaxin-1B1; Syntaxin-1B2; Syntaxin 1B1; Syntaxin 1B2; STX1B; STX1B1; STX1B2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 33kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Syntaxin-1B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinsons disease has also been suggested. [provided by RefSeq, Jan 2015].
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Subunit:
Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent.
Subcellular Location:
Isoform 1: Membrane. Single-pass type IV membrane protein.
Isoform 2: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.
Post-translational modifications:
Phosphorylated by CK2.
DISEASE:
Generalized epilepsy with febrile seizures plus 9 (GEFSP9) [MIM:616172]: An autosomal dominant neurologic disorder characterized by febrile and/or afebrile seizures manifesting in early childhood. Seizure are variable and include generalized tonic-clonic, atonic, myoclonic, complex partial, and absence types. Most patients have remission of seizures later in childhood with no residual neurologic deficits. Rarely, patients may show mild developmental delay or mild intellectual disabilities. {ECO:0000269|PubMed:25362483}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the syntaxin family.
Contains 1 t-SNARE coiled-coil homology domain.
Database links:Entrez Gene: 112755 Human
Entrez Gene: 6804 Human
Entrez Gene: 56216 Mouse
Entrez Gene: 24923 Rat
Omim: 186590 Human
SwissProt: P61267 Cow
SwissProt: P61266 Human
SwissProt: P61264 Mouse
SwissProt: P61265 Rat
SwissProt: P61268 Sheep
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.