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货号： bs-20316R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20316R-AF594
- 英文名称
- Anti-QPRT/QAPRTase /AF594
- 中文名称
- AF594标记的喹啉酸磷酸核糖基转移酶抗体
- 别 名
- NADC_HUMAN; Nicotinate nucleotide pyrophosphorylase (carboxylating); Nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; QPRT; QPRTase; Quinolinate phosphoribosyltransferase [decarboxylating]; Quinolinate phosphoribosyltransferase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human QPRT/QAPRTase
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Quinolinate phosphoribosyltransferase (QPRTase) is a major enzyme in the catabolism of quinolinate. Quinolinate is an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide, and pyrophosphate. Catabolism of quinolinate is vital due to the quinolinate’s neurotoxicity. Increased levels of quinolinate have been linked to neurodegenerative symptoms associated with meningitis and AIDS. QAPRTase has a seven-stranded alpha/beta-barrel domain which is similar in structure to the eight-stranded alpha/beta-barrel enzymes. The protein possesses a novel fold in comparison to other members of the PRTase family. This fold comprises a structure combining two domains. The structure is part alpha/beta barrel-like domain, and part alpha/beta N-terminal domain.
Function:
Involved in the catabolism of quinolinic acid (QA).
Subunit:
Hexamer formed by 3 homodimers.
Similarity:
Belongs to the nadC/modD family.
Database links:Entrez Gene: 614254 Cow
Entrez Gene: 607664 Dog
Entrez Gene: 100727900 Guinea pig
Entrez Gene: 100065768 Horse
Entrez Gene: 23475 Human
Entrez Gene: 100406642 Marmoset (common)
Omim: 606248 Human
SwissProt: Q3T063 Cow
SwissProt: Q15274 Human
Unigene: 513484 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.