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货号： bs-20693R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20693R-AF594
- 英文名称
- Anti-C-flanking peptide of NPY/AF594
- 中文名称
- AF594标记的C-侧翼肽NPY抗体
- 别 名
- Neuropeptide tyrosine; Neuropeptide Y precursor; NPY; PYY 4; PYY4; Y Neuropeptide; NPY_HUMAN; Pro-neuropeptide Y; CPON.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 3.3/8kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human C-flanking peptide of NPY
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter found in the brain and autonomic nervous system. NPY has been associated with a number of physiologic processes in the brain, including the regulation of energy balance, memory and learning, and epilepsy.The main effect is increased food intake and decreased physical activity. NPY is secreted by the hypothalamus, and in addition to increasing food intake, it increases the proportion of energy stored as fat and blocks nociceptive signals to the brain NPY also augments the vasoconstrictor effects of noradrenergic neurons.
Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Subcellular Location:
Secreted.
Tissue Specificity:
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Post-translational modifications:
The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Similarity:
Belongs to the NPY family.
Database links:Entrez Gene: 4852 Human
Entrez Gene: 109648 Mouse
Entrez Gene: 24604 Rat
Omim: 162640 Human
SwissProt: P01303 Human
SwissProt: P57774 Mouse
SwissProt: P68006 Rabbit
SwissProt: P07808 Rat
Unigene: 1832 Human
Unigene: 154796 Mouse
Unigene: 9714 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.