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货号： bs-20360R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20360R-AF594
- 英文名称
- Anti-GGH/AF594
- 中文名称
- AF594标记的γ-谷氨酰水解酶抗体
- 别 名
- Glutamyl hydrolase gamma; Conjugase; EC 3.4.19.9; folylpolygammaglutamyl hydrolase; gamma glutamyl hydrolase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase; GGH; GGH_HUMAN; gH.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 干细胞 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GGH
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
GGH is a 318 amino acid protein that is secreted into the extracellular space and is also localized to both the lysosome and the melanosome. Functioning as a hydrolase, GGH contains one gamma-glutamyl hydrolase domain through which it catalyzes the hydrolysis of polyglutamate sidechains from pteroylpolyglutamates, specifically hydrolyzing gamma-glutamyl bonds. Via its catalytic activity, GGH may play a role in the bioavailability and metabolic activity of pteroylpolyglutamates. Polymorphisms in the gene encoding GGH are associated with rheumatoid arthritis, inflammatory bowel disease and various cancers. The gene encoding GGH maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
Function:
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Subunit:
Homodimer.
Subcellular Location:
Secreted; extracellular space. Lysosome. Melanosome. While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity:
Belongs to the peptidase C26 family.
Contains 1 gamma-glutamyl hydrolase domain.
Database links:Entrez Gene: 8836 Human
Omim: 601509 Human
SwissProt: Q92820 Human
Unigene: 78619 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.