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货号： bs-20375R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20375R-AF594
- 英文名称
- Anti-HECTD2/AF594
- 中文名称
- AF594标记的E3连接酶抑制素受体2抗体
- 别 名
- FLJ16050; FLJ37306; HECD2_HUMAN; HECT domain containing 2; HECT domain containing protein 2; HECT domain-containing protein 2; Hectd2; OTTHUMP00000020086; OTTHUMP00000038605; Probable E3 ubiquitin protein ligase HECTD2; Probable E3 ubiquitin-protein ligase HECTD2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 88kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HECTD2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HECT (Homologous to the E6-AP Carboxyl Terminus) proteins are a large group of E3 ubiquitin-ligases that play a role in the specificity and selectivity of ubiquitylation. The human genome encodes at least 20 different HECT domain proteins, which are grouped into two classes based on their E2 specificity. HECT enzymes also regulate the trafficking of many receptors, transporters, viral proteins and channels. Since HECT proteins are involved in the degradation of vital tumor suppressor molecules, it is theorized that some may contribute to tumorigenesis. HECTD2 (HECT domain-containing protein 2) is a 776 amino acid E3 ubiquitin-ligase that characteristically accepts ubiquitin from an E2 ubquitin-conjugating enzyme and directly transfers the ubiquitin to targeted substrates. Recently, HECTD2 haplotypes have been linked to the susceptibility of acquiring human prion diseases such as Creutzfeldt-Jakob Disease and kuru, which present after a long, clinically silent incubation period that seems to be determined by factors such as genetic background.
Function:
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).
Similarity:
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Database links:Entrez Gene: 143279 Human
Entrez Gene: 226098 Mouse
Entrez Gene: 100172010 Orangutan
Entrez Gene: 309514 Rat
SwissProt: Q5U5R9 Human
SwissProt: Q8CDU6 Mouse
SwissProt: Q5RD78 Orangutan
Unigene: 596096 Human
Unigene: 61107 Mouse
Unigene: 24395 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.