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货号： bs-20327R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20327R-AF594
- 英文名称
- Anti-KCNT1/AF594
- 中文名称
- AF594标记的钾离子通道亚家族T成员1抗体
- 别 名
- bA100C15.2; EIEE14; ENFL5; KCa4.1; KCNT1; KCNT1_HUMAN; Potassium channel subfamily T member 1; Potassium channel, subfamily T, member 1; SLACK.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 通道蛋白 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 137kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KCNT1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Function:
Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).
Subcellular Location:
Cell membrane.
Tissue Specificity:
Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.
Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.
Similarity:
Belongs to the potassium channel family.
Calcium-activated (TC 1.A.1.3)
subfamily. KCa4.1/KCNT1 sub-subfamily.
Contains 1 RCK N-terminal domain.
Database links:Entrez Gene: 57582 Human
Entrez Gene: 227632 Mouse
Entrez Gene: 60444 Rat
Omim: 608167 Human
SwissProt: Q5JUK3 Human
SwissProt: Q6ZPR4 Mouse
SwissProt: Q9Z258 Rat
Unigene: 104950 Human
Unigene: 119462 Mouse
Unigene: 162642 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.