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货号： bs-20471R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20471R-AF594
- 英文名称
- Anti-Estrogen Related Receptor beta/AF594
- 中文名称
- AF594标记的雌激素相关受体β抗体
- 别 名
- Err 2; ERR b; ERR B2; ERR beta 2; ERR beta; Err2; ERRB 2; ERRb; ERRB2; ERRbeta 2; ERRbeta; ESR L2; ESRL 2; ESRL2; ESRRB; Estrogen receptor like 2; Estrogen receptor related 2; Estrrb; Nr3b2; Nuclear receptor ERRB2; Orphan nuclear receptor; Steroid hormone receptor ERR 2; Steroid hormone receptor ERR2; ERR2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 发育生物学 染色质和核信号 信号转导 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 56kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Estrogen Related Receptor beta
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Estrogen related receptor beta, a NR3 Steroid Receptor, has been shown to affect early placental development. Also it can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). It binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). Estrogen related receptor beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. Expression has been documented in mice in the extraembryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries. The ligand for the receptor is PPARgamma coactivator 1 (PGC-1) beta.
Function:
Nuclear receptor that binds DNA as monomer.
Subunit:
Monomer.
Subcellular Location:
Nuclear
DISEASE:
Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:608565]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Similarity:
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:Entrez Gene: 490798 Dog
Entrez Gene: 2103 Human
Entrez Gene: 26380 Mouse
Entrez Gene: 299210 Rat
Omim: 602167 Human
SwissProt: O95718 Human
SwissProt: Q61539 Mouse
SwissProt: P11475 Rat
Unigene: 337489 Human
Unigene: 435845 Human
Unigene: 235550 Mouse
Unigene: 104984 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.