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货号： bs-20422R-AF594 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20422R-AF594
- 英文名称
- Anti-Neogenin/AF594
- 中文名称
- AF594标记的神经细胞粘附蛋白NGN抗体
- 别 名
- NGN; Neo1; Neo 1; Neogenin; NEO1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 细胞粘附分子 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 156kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Neogenin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a cell surface protein that is a memberof the immunoglobulin superfamily. The encoded protein consists offour N-terminal immunoglobulin-like domains, six fibronectin typeIII domains, a transmembrane domain and a C-terminal internaldomain that shares homology with the tumor suppressor candidategene DCC. This protein may be involved in cell growth anddifferentiation and in cell-cell adhesion. Defects in this gene areassociated with cell proliferation in certain cancers. Alternatesplicing results in multiple transcript variants. [provided byRefSeq, Feb 2010].
Function:
Neogenin is one of several netrin-binding proteins. Neogenin functions as an Repulsive Guidance Molecule (RGM) receptor; RGM is implicated in axonal guidance and neural tube closure.
Subunit:
Interacts with RGMA. Interacts with MYO10
Subcellular Location:
Cell membrane; Single-pass type I membraneprotein.
Tissue Specificity:
Widely expressed and also in cancer celllines.
Similarity:
Belongs to the immunoglobulin superfamily. DCC family.
Contains 6 fibronectin type-III domains.
Contains 4 Ig-like C2-type (immunoglobulin-like)domains.
Database links:Entrez Gene: 4756 Human
Entrez Gene: 18007 Mouse
Entrez Gene: 81735 Rat
Omim: 601907 Human
SwissProt: Q92859 Human
SwissProt: P97798 Mouse
SwissProt: P97603 Rat
Unigene: 388613 Human
Unigene: 42249 Mouse
Unigene: 10667 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.