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货号： bs-17687R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17687R
- 英文名称
- MMP6/MPHOSPH6
- 中文名称
- 基质金属蛋白酶6抗体
- 别 名
- M phase phosphoprotein 6; M phase phosphoprotein 6 variant; M-phase phosphoprotein 6; MT-MMP-6; MMP 6; MMP; MPH6_HUMAN; MPHOSH6; MPHOSPH 6; Mphosph6; MPP 6; MPP; MPP6.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 细胞粘附分子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 19kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MMP6:1-80/160
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover. MT-MMP-6 (also known as MMP-25, MT6-MMP or Leukolysin) is the second GPI-anchored proteinase in the MMP family. Similar to MMP-3, MT-MMP-6 is able to cleave type IV collagen, Fibronectin, fibrin and gelatin. However, MT-MMP-6 cannot cleave Laminin-1 or activate progelatinase B. MT-MMP 6 is expressed in leukocytes, lung and spleen
Function:
RNA-binding protein that associates with the RNA exosome complex. Involved in the 3processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.
Subunit:
Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and SKIV2L2.
Subcellular Location:
Nucleus > nucleolus. Cytoplasm. Cytoplasmic in M phase.
Post-translational modifications:
Phosphorylated in M (mitotic) phase.
Similarity:
Belongs to the MPP6 family.
SWISS:
Q99547
Gene ID:
10200
Database links:Entrez Gene: 10200Human
Entrez Gene: 68533Mouse
Omim: 605500Human
SwissProt: Q99547Human
SwissProt: Q9D1Q1Mouse
Unigene: 344400Human
Unigene: 181836Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Paraformaldehyde-fixed, paraffin embedded (Rat urinary bladder); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP6/MPHOSPH6) Polyclonal Antibody, Unconjugated (bs-17687R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP6/MPHOSPH6) Polyclonal Antibody, Unconjugated (bs-17687R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.