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货号： bs-23087R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23087R-AF555
- 英文名称
- Anti-FCRLM1/AF555
- 中文名称
- AF555标记的FCRLM1蛋白抗体
- 别 名
- Fc receptor homolog expressed in B cells; Fc receptor like A; Fc receptor like and mucin like 1; Fc receptor like and mucin like protein 1; Fc receptor like protein; Fc receptor related protein X; FCRL; FCRL1; FCRLA_HUMAN; FCRLa; FCRLb; FCRLc1; FCRLc2; FCRLd; FCRLe; FCRLX; FcRX; FREB; MGC4595; RP11 474I16.5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FCRLM1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Function:
FCRLM1 belongs to a family of receptors for the Fc fragment of IgG, or FCGRs which are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. FCRLM1 may be involved in B-cell differentiation and lymphomagenesis.
Subunit:
Monomer or homodimer; disulfide-linked.
Subcellular Location:
Secreted. Cytoplasm.
Tissue Specificity:
Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Database links:Entrez Gene: 84824Human
Omim: 606891Human
SwissProt: Q7L513Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.