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货号： bs-23062R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23062R-AF555
- 英文名称
- Anti-Involucrin/AF555
- 中文名称
- AF555标记的囊包蛋白/内披蛋白抗体
- 别 名
- INVO_MOUSE; involucrin; ivl.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞周期蛋白 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 64kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse Involucrin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subunit:
Directly or indirectly cross-linked to cornifelin (CNFN).
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Keratinocytes of epidermis and other stratified squamous epithelia.
Post-translational modifications:
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
Similarity:
Belongs to the involucrin family.
Database links:Entrez Gene: 3713 Human
Entrez Gene: 16447 Mouse
Entrez Gene: 60583 Rat
Omim: 147360 Human
SwissProt: P07476 Human
SwissProt: P48997 Mouse
SwissProt: P48998 Rat
Unigene: 516439 Human
Unigene: 207365 Mouse
Unigene: 142591 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
套膜蛋白又称内披蛋白或囊包蛋白，与毛透明蛋白共同构成角质细胞包膜支架的蛋白质。在角质细胞分化时，首先出现在表皮棘层的上层细胞中的标志性蛋白质，该蛋白在角质细胞和其他复层扁平上皮合成的蛋白。最初存在于细胞质中，然后通过转谷氨酰胺酶的作用，转变为交联的膜蛋白。