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货号： bs-17799R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17799R-AF555
- 英文名称
- Anti-phospho-MYL9 (Thr19 + Ser20)/AF555
- 中文名称
- AF555标记的磷酸化肌球蛋白调节多肽9抗体
- 别 名
- MYL9 (phospho T19 + S20); p-MLC(Thr19 + Ser20); phospho-MLC(Thr19 + Ser20); p-Myosin light chain(Thr19 + Ser20); MYL9_HUMAN; Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; MLC2; MRLC1; MYRL2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 心血管 细胞生物 信号转导 干细胞 细胞骨架 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Danio
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 20kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human MYL9 around the phosphorylation site of Thr19 + Ser20
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MYL9 is the myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. MYL9 protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for MYL9 and the deduced 172-amino acid protein is highly conserved, with only 3 differences between the human and chicken proteins. Light chain phosphorylation causes the folded monomeric form of myosin to extend and assemble into filaments. This observation established the involvement of the MYL9 in conformational transitions of smooth muscle myosin.
Function:
Myosin light chain (MLC) is a subunit of the conventional myosins (e.g. myosin II). In smooth muscle and non-muscle cells conventional myosins mediate a wide variety of contractile events including cytokinesis, cell motility, and smooth muscle contraction. MLC is phosphorylated by multiple serine-threonine kinases such as Rho-kinase and PAK, however myosin light chain kinase (MLCK) acts as the primary kinase. Contractile activity of conventional myosins is regulated by phosphorylation of MLC on several residues.
Subunit:
Myosin is an hexamer of 2 heavy chains and 4 light chains.
Tissue Specificity:
Smooth muscle tissues and in some, but not all, nonmuscle cells.
Post-translational modifications:
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).
Similarity:
Contains 3 EF-hand domains.
Database links:Entrez Gene: 10398Human
Entrez Gene: 85366Human
Entrez Gene: 228785Mouse
Entrez Gene: 98932Mouse
Entrez Gene: 117558Rat
Entrez Gene: 296313Rat
Omim: 606566Human
Omim: 609905Human
SwissProt: P20689Human
SwissProt: P24844Human
SwissProt: Q8VCR8Mouse
SwissProt: Q9CQ19Mouse
SwissProt: P20689Rat
SwissProt: Q64122Rat
Unigene: 504687Human
Unigene: 271770Mouse
Unigene: 228729Rat
Unigene: 6870Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.