产品中心
当前位置：首页>产品中心Anti-VGLUT3/SLC17A8/AF555
货号： bs-8701R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8701R-AF555
- 英文名称
- Anti-VGLUT3/SLC17A8/AF555
- 中文名称
- AF555标记的囊泡谷氨酸转运蛋白3抗体
- 别 名
- deafness autosomal dominant 25; DFNA 25; DFNA25; SLC17A8; Solute carrier family 17 (sodium dependent inorganic phosphate cotransporter) member 8; Solute carrier family 17 member 8; Vesicular glutamate transporter 3; VGLU3_HUMAN; VGLUT 3; VGluT3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 65kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human VGLUT3/SLC17A8
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular Location:
Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Membrane. Cell junction > synapse >synaptosome.
Tissue Specificity:
Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.
DISEASE:
Defects in SLC17A8 are the cause of deafness autosomal dominant type 25 (DFNA25) [MIM:605583]. DFNA25 is a form of sensorineural hearing loss. The expression of DFNA25 deafness is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged.
Similarity:
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
Database links:Entrez Gene: 246213Human
Entrez Gene: 216227Mouse
Entrez Gene: 266767Rat
Omim: 607557Human
SwissProt: Q8NDX2Human
SwissProt: Q8BFU8Mouse
SwissProt: Q7TSF2Rat
Unigene: 116871Human
Unigene: 233921Mouse
Unigene: 84876Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.