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货号： bs-19191R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19191R-AF555
- 英文名称
- Anti-NEI3/AF555
- 中文名称
- AF555标记的DNA糖基化酶FPG2抗体
- 别 名
- 123;AI449477;BC034753;C85903;DNA glycosylase FPG2;DNA glycosylase hFPG2;DNA glycosylase/AP lyase Neil3;EC 3.2.2.-;EC 4.2.99.18;Endonuclease 8-like 3;Endonuclease VIII-like 3;FGP2;FLJ10858;FPG2;hFPG2;hNEI3;MGC27861;MGC36916;Nei endonuclease VIII-like 3 (E. coli);nei endonuclease VIII-like 3;Nei like 3 (E. coli);Nei-like protein 3;NEIL3;NEIL3_HUMAN;OTTHUMP00000218810;RGD1310562.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NEI3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Function:
Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected.
Subcellular Location:
Nucleus.
Tissue Specificity:
Detected in thymus and testis. Expressed at higher levels in tumor tissue than in the corresponding normal tissues except for pancreas and testis where expression is higher in normal than tumor tissue.
Similarity:
Belongs to the FPG family.
Contains 1 FPG-type zinc finger.
Contains 1 RanBP2-type zinc finger.
Database links:Entrez Gene: 55247Human
Entrez Gene: 234258Mouse
Entrez Gene: 290729Rat
Omim: 608934Human
SwissProt: Q8TAT5Human
SwissProt: Q8K203Mouse
SwissProt: D3ZKJ8Rat
Unigene: 405467Human
Unigene: 281749Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.