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货号： bs-18964R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18964R-AF555
- 英文名称
- Anti-MMP25/AF555
- 中文名称
- AF555标记的基质金属蛋白酶25抗体
- 别 名
- Leukolysin; Leukolysin; matrix metallopeptidase 25; matrix metallopeptidase like 1; matrix metalloproteinase 20; Matrix Metalloproteinase 25; Matrix Metalloproteinase 25; Matrix metalloproteinase 25 precursor; Membrane type 6 Matrix Metalloproteinase; Membrane type Matrix Metalloproteinase 6; MMP 25; MMP20; MMP20A; MMP20A; MMPL1; MT MMP 6; MT6 MMP.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 65kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MMP25
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Function:
May activate progelatinase A.
Subcellular Location:
Cell Membrane; lipid-anchor; GPI-anchor.
Tissue Specificity:
Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase
Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.
Database links:Entrez Gene: 64386Human
Entrez Gene: 240047Mouse
Omim: 608482Human
SwissProt: Q9NPA2Human
SwissProt: Q3U435Mouse
Unigene: 654979Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.