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货号： bs-18930R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18930R-AF555
- 英文名称
- Anti-MIA3/AF555
- 中文名称
- AF555标记的黑色素瘤抑制活性蛋白3抗体
- 别 名
- ARNT; C219 reactive peptide; C219-reactive peptide; D320; Melanoma inhibitory activity family, member 3; Melanoma inhibitory activity protein 3; Mia3; MIA3_HUMAN; RP11-378J18.4; TANGO; TANGO1; Transport and Golgi organization protein 1; UNQ6077.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 214kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MIA3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1.
Subcellular Location:
Endoplasmic reticulum membrane. Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane.
Tissue Specificity:
Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue.
Similarity:
Belongs to the MIA/OTOR family.
Tango1 subfamily.
Contains 1 SH3 domain.
Database links:Entrez Gene: 375056Human
Omim: 613455Human
SwissProt: Q5JRA6Human
Unigene: 118474Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.