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货号： bs-18811R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18811R-AF555
- 英文名称
- Anti-METT10D/AF555
- 中文名称
- AF555标记的甲基样蛋白16抗体
- 别 名
- 2610100D03Rik; 2810013M15Rik; A830095F14Rik; AI846133; Methyltransferase 10 domain containing; Methyltransferase like 16; METT10D; MGC3329; OTTMUSP00000006473; Putative methyltransferase METT10D; RP23-174M12.2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Cat, Chimpanzee,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 62kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human METT10D
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
METT10D is a 562 amino acid protein that belongs to the METTL16/rlmF family and methyltransferase superfamily. A putative methyltransferase, METT10D exists as two alternatively spliced isoforms and undergoes phosphorylation in response to DNA damage, most likely by Atm or ATR. The gene encoding METT10D maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is linked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes.
Function:
Probable methyltransferase.
Similarity:
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
Database links:Entrez Gene: 468142Chimpanzee
Entrez Gene: 100765063 Chinese Hamster
Entrez Gene: 480655Dog
Entrez Gene: 100734997 Guinea pig
Entrez Gene: 79066Human
Entrez Gene: 67493Mouse
Entrez Gene: 360568Rat
SwissProt: Q86W50Human
SwissProt: Q9CQG2Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.