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货号： bs-18801R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18801R-AF555
- 英文名称
- Anti-MGLUR5/AF555
- 中文名称
- AF555标记的代谢型谷氨酸受体5B抗体
- 别 名
- MGLUR5B; Glutamate receptor metabotropic 5; GPRC1E; GRM 5; GRM5; Metabotropic glutamate receptor 5; mGlu5; mGluR5; mGluR5a; mGluR5b; Metabotropic glutamate receptor 5 variant F; Metabotropic Glutamate Receptor 5b; Metabotropic glutamate receptor 5 variant G; Metabotropic glutamate receptor 5 variant H; PPP1R86; GRM5_HUMAN;
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Horse, Sheep, Monkey,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 130kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MGLUR5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals.
Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteKns) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generatesa calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Subunit:
The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity).
Subcellular Location:
Cell Membrane
Similarity:
Belongs to the G-protein coupled receptor 3 family.
Database links:Entrez Gene: 2915Human
Entrez Gene: 108071Mouse
Entrez Gene: 24418Rat
Omim: 604102Human
SwissProt: P41594Human
SwissProt: Q3UVX5Mouse
SwissProt: P31424Rat
Unigene: 147361Human
Unigene: 29972Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.