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货号： bs-18788R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18788R-AF555
- 英文名称
- Anti-MEPCE/AF555
- 中文名称
- AF555标记的MEPCE蛋白抗体
- 别 名
- 7SK snRNA methylphosphate capping enzyme; BCDIN3; Bicoid interacting protein 3 homolog; Bin3 bicoid interacting 3; Bin3 bicoid interacting 3 homolog (Drosophila); Bin3 bicoid interacting 3 homolog; Bin3 homolog; FLJ20257; MePCE; Methylphosphate capping enzyme.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, Rhesus monkey
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 74kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MEPCE
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MEPCE belongs to the methyltransferase superfamily and contains one BIN3 domain. It is an S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it. MEPCE is expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. It is weakly or not expressed in other tissues.
Function:
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.
Subunit:
Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, MEPCE/BCDIN3, SART3 proteins and 7SK and U6 snRNAs.
Tissue Specificity:
Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues.
Similarity:
Belongs to the methyltransferase superfamily.
Contains 1 Bin3-type SAM domain.
Database links:Entrez Gene: 472462Chimpanzee
Entrez Gene: 489839Dog
Entrez Gene: 100068939Horse
Entrez Gene: 56257Human
Entrez Gene: 231803Mouse
Entrez Gene: 304361Rat
Omim: 611478Human
SwissProt: Q7L2J0Human
SwissProt: Q8K3A9Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.