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货号： bs-18775R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18775R-AF555
- 英文名称
- Anti-MEGF11/AF555
- 中文名称
- AF555标记的MEGF11蛋白抗体
- 别 名
- KIAA1781; MEG11_HUMAN; Megf11; Multiple EGF-like domains protein 11; multiple EGF-like-domains 11; Multiple epidermal growth factor-like domains 11; Multiple epidermal growth factor-like domains protein 11.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 110kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MEGF11
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MEGF11 is a 1,044 amino acid single-pass type I membrane protein that belongs to the MEGF family. MEGF11 exists as a homopolymer that primarily localizes to protruding lamellipodia in an irregular, mosaic-like adhesion pattern. Expressed at high levels in adult and fetal brain and adult spinal cord, MEGF11 is found at lower levels in kidney, ovary and heart. MEGF11 contains fourteen EGF-like domains, one EMI domain, and undergoes alternative splicing events to produce four isoforms. The gene encoding MEGF11 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Function:
May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note: Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.
Similarity:
Belongs to the MEGF family.
Contains 14 EGF-like domains.
Contains 1 EMI domain.
Database links:Entrez Gene: 84465Human
Entrez Gene: 214058Mouse
Entrez Gene: 691517Rat
Entrez Gene: 563468Zebrafish
Omim: 612454Human
SwissProt: A6BM72Human
SwissProt: Q80T91Mouse
Unigene: 712886Human
Unigene: 127721Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.