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货号： bs-18639R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18639R-AF555
- 英文名称
- Anti-Malectin/MLEC/AF555
- 中文名称
- AF555标记的Malectin蛋白抗体
- 别 名
- KIAA0152; Malectin; Mlec; MLEC_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Turkey
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 29kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Malectin/MLEC
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MLEC is a 292 amino acid single-pass type I membrane protein of the endoplasmic reticulum that belongs to the malectin family and is thought to play a role in N-glycosylation. MLEC may function as a carbohydrate-binding protein that preferentially binds Glc2-N-glycan. The gene encoding MLEC maps to human chromosome 12, which makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster, encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms which vary in severity depending on the extent of mosaicism. It is most severe in cases of complete trisomy.
Function:
Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the malectin family.
Database links:Entrez Gene: 9761Human
Entrez Gene: 109154Mouse
Entrez Gene: 304543Rat
Entrez Gene: 569613Zebrafish
Omim: 613802Human
SwissProt: Q14165Human
SwissProt: Q6ZQI3Mouse
SwissProt: Q5FVQ4Rat
SwissProt: A9C3P0Zebrafish
Unigene: 728853Human
Unigene: 153963Mouse
Unigene: 162140Rat
Unigene: 148402Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.