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货号： bs-18615R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18615R-AF555
- 英文名称
- Anti-MAFG/AF555
- 中文名称
- AF555标记的转录因子MAFG抗体
- 别 名
- AA545192; Basic leucine zipper transcription factor MafG; C630022N07Rik; hMAF; MAFG; MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); MAFG_HUMAN; MGC13090; MGC20149; RP23 84C12.9; Transcription factor MafG; V maf musculoaponeurotic fibrosarcoma oncogene homolog G; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 18kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MAFG
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+).
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in skeletal muscle. Also expressed in heart and brain.
Post-translational modifications:
Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
Sumoylation at Lys-14 is required for active transcriptional repression.
Similarity:
Belongs to the bZIP family. Maf subfamily.
Contains 1 bZIP domain.
Database links:Entrez Gene: 4097Human
Entrez Gene: 17134Mouse
Entrez Gene: 64188Rat
Omim: 602020Human
SwissProt: O15525Human
SwissProt: O54790Mouse
SwissProt: Q76MX4Rat
Unigene: 252229Human
Unigene: 268010Mouse
Unigene: 292957Mouse
Unigene: 393664Mouse
Unigene: 17361Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.