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货号： bs-18604R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18604R-AF555
- 英文名称
- Anti-LY6D/AF555
- 中文名称
- AF555标记的淋巴细胞抗原Ly6D抗体
- 别 名
- E48 antigen; LY 6D; LY-6D;Lymphocyte antigen 6 complex; LY6D_HUMAN; Lymphocyte antigen 6 complex locus D; Lymphocyte antigen D; Lymphocyte antigen 6D.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 淋巴细胞 t-淋巴细胞 b-淋巴细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 8.4kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LY6D
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
Ly-6D is a 128 amino acid glycoprotein that is expressed in squamous cell carcinoma cell lines and squamous cell epithelia tissue. Ly-6D contains a signal peptide, 2 theoretical phosphorylation sites and 3 putative myristoylation sites. Upregulation of the gene encoding Ly-6D in head and neck cancers is associated with poor prognosis and high expression of Ly-6D has been linked to enhanced cell migration. Ly-6D is frequently used as a molecular marker for diagnosis and therapy of head-and-neck squamous cell carcinoma (HNSCC). It has been suggested that Ly-6D may regulate the expression levels of certain fucosylated E-selectin ligands and protein FX, a protein that contributes to the last step in the synthesis of GDP-L-fucose, in HNSCC cell lines. This finding is indicative that Ly-6D may regulate tumor cell adhesion in inflamed vessel walls that express E-selectin.
Function:
May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.
Subcellular Location:
Cell membrane; Lipid-anchor ?GPI-anchor
Tissue Specificity:
Expressed exclusively at the outer cell surface of transitional epithelia and the keratinocyte of stratified squamous epithelia.
Similarity:
Contains 1 UPAR/Ly6 domain.
Database links:
http://www.ncbi.nlm.nih.gov/protein/2501524
UniProtKB/Swiss-Prot: Q14210.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.