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货号： bs-17375R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17375R
- 英文名称
- HP1BP3
- 中文名称
- 异染色质蛋白1结合蛋白3抗体
- 别 名
- Heterochromatin protein 1, binding protein 3; HP1 BP74; HP1BP 3; MGC28927; MGC43701; MGC72624; OTTHUMP00000002717; OTTHUMP00000002719; OTTHUMP00000002720; Protein HP1 BP74; RP5 930J4.3.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 结合蛋白 细胞类型标志物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 61kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HP1BP3:301-400/553
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
HP1BP3 is a 553 amino acid nuclear and chromosomal protein that exists as a component of heterochromatin. As such, HP1BP3 is involved in chromatin function and structure. Existing as four alternatively spliced isoforms, HP1BP3 undergoes post-translational phosphorylation, most likely by either ATM or ATR. HP1BP3 contains three H15 (linker histone H1/H5 globular) domains and is encoded by a gene that maps to human chromosome 1p36.12. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.
Function:
HP1BP3 is a component of heterochromatin and may be involved in chromatin structure and function.
Subcellular Location:
Nuclear
SWISS:
Q5SSJ5
Gene ID:
50809
Database links:Entrez Gene: 50809Human
Entrez Gene: 15441Mouse
Entrez Gene: 313647Rat
SwissProt: Q5SSJ5Human
SwissProt: Q3TEA8Mouse
SwissProt: Q6P747Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
Jurkat cell(human) Lysate at 30 ug
Panc1 cell(human) Lysate at 30 ug
Primary: Anti- HP1BP3 (bs-17375R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 61kD
Observed band size: 61kD
Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HP1BP3) Polyclonal Antibody, Unconjugated (bs-17375R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.