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货号： bs-18480R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18480R-AF555
- 英文名称
- Anti-ZDHHC2/ZNF372/AF555
- 中文名称
- AF555标记的锌指蛋白372抗体
- 别 名
- DHHC-2; Palmitoyltransferase ZDHHC2; Ream; Rec; Reduced expression associated with metastasis protein; Reduced expression in cancer protein; ZDHC2_HUMAN; Zdhhc2; Zinc finger DHHC domain-containing protein 2; Zinc finger protein 372; ZNF372.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 锌指蛋白 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Monkey,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 42kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZDHHC2/ZNF372
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ZDHHC2 is a 367 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. The ubiquitously expressed ZDHHC2 protein functions as a palmitoyltransferase that uses palmitoyl-CoA and catalyzes the conversion of target proteins, namely GAP-43 and PSD-95, to S-palmitoyl proteins. Defects in the gene encoding ZDHHC2 are found in colorectal cancer and hepatocellular carcinoma, suggesting a role for ZDHHC2 in tumorigenesis. The gene encoding human ZDHHC2 maps to chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.
Subcellular Location:
Membrane.
Tissue Specificity:
Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.
DISEASE:
Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.
Similarity:
Belongs to the DHHC palmitoyltransferase family.
Contains 1 DHHC-type zinc finger.
Database links:Entrez Gene: 51201Human
Entrez Gene: 70546Mouse
Entrez Gene: 246326Rat
SwissProt: Q9UIJ5Human
SwissProt: P59267Mouse
Unigene: 726197Human
Unigene: 34326Mouse
Unigene: 17310Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.