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货号： bs-18435R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18435R-AF555
- 英文名称
- Anti-LSM11/AF555
- 中文名称
- AF555标记的LSM11蛋白抗体
- 别 名
- 2210404M20Rik; LSM11 homolog, U7 small nuclear RNA associated; LSM11, U7 small nuclear RNA associated; U7 snRNA-associated Sm-like protein LSm11.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LSM11
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LSM11 is a 39.5 kDa protein that is a component of a specialized SMN complex also containing Lsm10. Lsm11 not only specifies the assembly of the U7 Sm core but also fulfills an important role in U7 snRNP-mediated histone mRNA processing.
Function:
Component of the U7 snRNP complex that is involved in the histone 3-end pre-mRNA processing By similarity. Increases U7 snRNA levels but not histone 3-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.
Subunit:
Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with LSM10, SMN, SNRPB and ZNF473. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 By similarity. Interacts (via the Sm domains) with CLNS1A. Interacts with PRMT5 and WDR77
Subcellular Location:
Nuclear
Post-translational modifications:
Not methylated
Similarity:
Belongs to the snRNP Sm proteins family.
Database links:Entrez Gene: 134353Human
Entrez Gene: 72290Mouse
SwissProt: P83369Human
SwissProt: Q5SUH5Mouse
SwissProt: Q8BUV6Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.