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货号： bs-18316R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18316R-AF555
- 英文名称
- Anti-LMOD2/AF555
- 中文名称
- AF555标记的平滑肌蛋白LMOD2抗体
- 别 名
- C-LMOD; Cardiac leiomodin; Leiomodin 2 (cardiac); Leiomodin-2; LMOD2; LMOD2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 发育生物学 信号转导 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 62kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LMOD2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Members of the Leiomodin protein family are closely related to the tropomodulin family of actin filament pointed end-capping proteins. Leiomodins are actin-binding proteins that act as strong filament nucleators in muscle cells. Leiomodin 1 is highly expressed in a variety of tissues that contain smooth muscle, therefore it is also known as smooth muscle Leiomodin, or SM-Lmod. Also designated C-Lmod, Leiomodin 3 is found in several types of fetal tissue and is involved in tropomyosin binding. Leiomodin 2, also known as C-LMOD or LMOD2, is a 547 amino acid protein that is specifically expressed in heart and skeletal muscles. Leiomodin 2 binds to tropomyosin and may block the elongation and depolymerization of actin filaments at their pointed end. Leiomodin 2 is encoded by a gene that is located near the hypertrophic cardiomyopathy locus CMH6 on chromosome 7, suggesting that Leiomodin 2 may be involved in that disease process. Leiomodin 2 is expressed as three alternatively spliced variants.
Function:
May block the elongation and depolymerization of the actin filaments at the pointed end.
Tissue Specificity:
Specifically expressed in heart and skeletal muscles. Not expressed in other tissues.
Similarity:
Belongs to the tropomodulin family.
Contains 1 WH2 domain.
Database links:Entrez Gene: 442721Human
Entrez Gene: 93677Mouse
Omim: 608006Human
SwissProt: Q6P5Q4Human
SwissProt: Q3UHZ5Mouse
Unigene: 592260Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.