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货号： bs-17271R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17271R
- 英文名称
- SCARA5
- 中文名称
- 清道夫受体A亚型5抗体
- 别 名
- FLJ23907; MGC45780; NET33; SCAR5_HUMAN; SCARA 5; scara5; Scavenger receptor class A member 5; Scavenger receptor class A, member 5 (putative); Scavenger receptor class A, member 5; Scavenger receptor hlg; Tesr; Testis expressed scavenger receptor.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 54kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SCARA5:231-330/495 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
SCARA5 is a 495 amino acid cell membrane protein. SCARA5 is expressed at high levels in testis, with highest levels specifically found in specific populations of epithelial cells and Sertoli cells. SCARA5 forms a homotrimer single-pass type II membrane complex present on the surface of the plasma membrane. Cells transfected with SCARA5 were able to bind particular gram-positive and gram-negative bacteria, suggesting a possible role for SCARA5 in immunity to infection. It has also been suggested that SCARA5 may be involved in transferrin delivery pathways. Expressed as four isoforms produced by alternative splicing, SCARA5 contains one collagen-like domain and one SRCR domain.
Function:
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Subunit:
Homotrimer.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the SCARA5 family.
Contains 1 collagen-like domain.Contains 1 SRCR domain.
SWISS:
Q6ZMJ2
Gene ID:
286133
Database links:Entrez Gene: 286133Human
Entrez Gene: 71145Mouse
Omim: 611306Human
SwissProt: Q6ZMJ2Human
SwissProt: Q8K299Mouse
Unigene: 591833Human
Unigene: 83840Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-SCARA5 (bs-17271R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54 kD
Observed band size: 54 kD
Tissue/cell: Mouse liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-SCARA5 Polyclonal Antibody, Unconjugated(bs-17271R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining