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货号： bs-10907R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10907R-AF555
- 英文名称
- Anti-Myosin-10 /AF555
- 中文名称
- AF555标记的肌球蛋白10抗体
- 别 名
- MYH10_HUMAN; Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; Non-muscle myosin heavy chain B; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 229kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Myosin-10
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
Subunit:
Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC.
Subcellular Location:
Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.
Tissue Specificity:
Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
Post-translational modifications:
Phosphorylated by ABL2 (By similarity).
Similarity:
Contains 1 IQ domain.
Contains 1 myosin head-like domain.
Database links:Entrez Gene: 4628 Human
Entrez Gene: 317655 Cow
Entrez Gene: 77579 Mouse
Entrez Gene: 79433 Rat
Omim: 160776 Human
SwissProt: Q27991 Cow
SwissProt: P35580 Human
SwissProt: Q5SV64 Mouse
SwissProt: Q61879 Mouse
SwissProt: Q8BXF2 Mouse
SwissProt: Q9JLT0 Rat
Unigene: 16355 Human
Unigene: 218233 Mouse
Unigene: 98166 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.