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货号： bs-16758R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16758R-AF555
- 英文名称
- Anti-KLHDC2/AF555
- 中文名称
- AF555标记的肝癌相关抗原33抗体
- 别 名
- HCLP-1; Hepatocellular carcinoma-associated antigen 33; Host cell factor homolog LCP; Host cell factor-like protein 1; Kelch domain containing 2; Kelch domain-containing protein 2; KLDC2_HUMAN; KLHDC2; LCP.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 46kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KLHDC2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
KLHDC2 is a 406 amino acid protein that contains six kelch repeats. Localizing to the nucleus, KLHDC2 is widely expressed, with high levels found in muscle, heart, pancreas and liver. KLHDC2 interacts directly with CREB3, repressing CREB3-mediated transcription. Existing as two alternatively spliced isoforms, the gene encoding KLHDC2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimers disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Function:
Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.
Similarity:
Contains 6 Kelch repeats.
Database links:Entrez Gene: 23588Human
Entrez Gene: 69554Mouse
Entrez Gene: 299113Rat
Omim: 611280Human
SwissProt: Q9Y2U9Human
SwissProt: Q4G5Y1Mouse
SwissProt: Q3KRE6Rat
Unigene: 509264Human
Unigene: 234368Mouse
Unigene: 129179Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.