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货号： bs-16076R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16076R-AF555
- 英文名称
- Anti-FFAR3/GPR42/AF555
- 中文名称
- AF555标记的G蛋白偶联受体42抗体
- 别 名
- FFA3R; Ffar3; FFAR3_HUMAN; Free fatty acid receptor 3; G protein coupled receptor 41; G-protein coupled receptor 41; gpcr41; GPR41; gpr42.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 结合蛋白 G蛋白偶联受体 细胞骨架 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FFAR3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. GPRs translate extracellular signals into intracellular signals (a process called G-protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR41 (G-protein coupled receptor 41), also known as FFAR3 (Free fatty acid receptor 3), is a 346 amino acid multi-pass membrane protein that belongs to the G protein-coupled receptor family. Expressed at high levels in adipose tissue and at lower levels throughout the body, GPR41 functions as a receptor for short chain fatty acids via elevation of intracellular calcium levels and inhibition of adenylyl cyclase.
Function:
Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate >formate.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Highest level in adipose tissue, and lower expression across all tissues tested.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 2865Human
Omim: 603821Human
SwissProt: O14843Human
Unigene: 248055Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.