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货号： bs-10622R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10622R-AF555
- 英文名称
- Anti-COPT2/AF555
- 中文名称
- AF555标记的CTR1抗体
- 别 名
- AI604396; Copper transporter 2; COPT2; COPT2_HUMAN; CTR2; hCTR2; MGC117640; Probable low affinity copper uptake protein 2; RP23 64F17.2; SLC31A2; Solute carrier family 31 member 2; Solute carrier family 31, member 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human COPT2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The activity of a diverse subset of enzymes relies on the essential nutrient copper to perform important processes including signaling to the transcription and protein trafficking machinery, oxidative phosphorylation, iron mobilization, neuropeptide maturation, and normal development. Copper uptake requires tight regulation to ensure that sufficient copper is present in the cell to drive vital cellular processes, while avoiding the accumulation of copper to toxic levels. The copper transporter 2 (COPT2), also designated CTR2 or Solute carrier family 31 member 2 (SLC31A2), is a 143 amino acid protein mediates the uptake of copper in mammalian cells. COPT2 has been shown to localize to the plasma membrane, endosomes and lysosomes, where it plays a role in maintaining copper homeostasis. COPT2 also mediates the uptake of the chemotherapeutic drugs cisplatin and carboplatin and may modulate the sensitivity and toxicity of these drugs.
Function:
Involved in low-affinity copper uptake (Potential).
Subcellular Location:
Membrane; Multi-pass membrane protein (Probable).
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.
Similarity:
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
Database links:Entrez Gene: 1318 Human
Entrez Gene: 20530 Mouse
Omim: 603088 Human
SwissProt: O15432 Human
SwissProt: Q9CPU9 Mouse
Unigene: 24030 Human
Unigene: 292539 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.