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货号： bs-14051R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14051R-AF555
- 英文名称
- Anti-CREB3L1/AF555
- 中文名称
- AF555标记的环腺苷酸应答元件结合蛋白3样蛋白1抗体
- 别 名
- BBF-2 homolog; CAMP responsive element binding protein 3 like 1; cAMP-responsive element-binding protein 3-like protein 1; CR3L1_HUMAN; Creb3l1; Cyclic AMP responsive element binding protein 3 like protein 1; OASIS; Old astrocyte specifically-induced substance; Processed cyclic AMP-responsive element-binding protein 3-like protein 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 染色质和核信号 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CREB3L1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
Function:
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
Subcellular Location:
Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Tissue Specificity:
Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
Post-translational modifications:
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.
Database links:Entrez Gene: 90993Human
Entrez Gene: 26427Mouse
Entrez Gene: 362165Rat
SwissProt: Q96BA8Human
SwissProt: Q9Z125Mouse
SwissProt: Q66HA2Rat
Unigene: 405961Human
Unigene: 10353Mouse
Unigene: 24541Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.