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货号： bs-14038R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14038R-AF555
- 英文名称
- Anti-CPSF6/AF555
- 中文名称
- AF555标记的剪切及多聚腺苷酸化特异性因子6蛋白抗体
- 别 名
- CFIm68; Cleavage and polyadenylation specificity factor 68 kDa subunit; Cleavage and polyadenylation specificity factor subunit 6; CPSF 68 kDa subunit; Cpsf6; CPSF6_HUMAN; HPBRII 4; HPBRII 7; Pre mRNA cleavage factor Im 68 kDa subunit; Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPBRII 4/7; Protein HPBRII-4/7.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 59kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CPSF6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is one subunit of a cleavage factor required for 3 RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3 end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Function:
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.
Subcellular Location:
Nucleus. In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the RRM CPSF6/7 family.
Contains 1 RRM (RNA recognition motif) domain.
Database links:Entrez Gene: 11052Human
Entrez Gene: 417844Chicken
Entrez Gene: 768231Cow
Entrez Gene: 432508Mouse
Entrez Gene: 299811Rat
Entrez Gene: 446580 Xenopus laevis
Omim: 604979Human
SwissProt: Q5ZL34Chicken
SwissProt: Q0P5D2Cow
SwissProt: Q16630Human
SwissProt: Q6NVF9Mouse
SwissProt: Q6DDW4 Xenopus laevis
Unigene: 369606Human
Unigene: 478881Mouse
Unigene: 478884Mouse
Unigene: 479892Mouse
Unigene: 7296 Xenopus laevis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.