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货号： bs-4122R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4122R-AF555
- 英文名称
- Anti-MAX protein/AF555
- 中文名称
- AF555标记的Myc基因相关X因子抗体
- 别 名
- bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; Helix loop helix zipper protein; MAX protein; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; Myc associated factor X; Myc binding novel HLH/LZ protein; Orf 1; Orf1; Protein max; MAX_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 18kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MAX protein
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MAX is a basic helix-loop-helix, leucine zipper protein that forms heterodimers with MYC and MAD. It is involved in regulating gene expression.
Function:
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9.
Subcellular Location:
Nucleus.
Tissue Specificity:
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Post-translational modifications:
Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
Similarity:
Belongs to the MAX family.
Contains 1 bHLH (basic helix-loop-helix) domain.
Database links:Entrez Gene: 4149 Human
Entrez Gene: 17187 Mouse
Entrez Gene: 60661 Rat
Omim: 154950 Human
SwissProt: P52162 Chicken
SwissProt: P61244 Human
SwissProt: P28574 Mouse
SwissProt: P52164 Rat
Unigene: 285354 Human
Unigene: 4210 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.