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货号： bs-6190R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6190R-AF555
- 英文名称
- Anti-Thyroxine Binding Globulin/AF555
- 中文名称
- AF555标记的甲状腺素结合球蛋白抗体
- 别 名
- Serpin A7; Serpin A 7; SerpinA7; Serpin-A7; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7; SERPINA7; T4 binding globulin; TBG; THBG_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 生长因子和激素 结合蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 44kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Thyroxine Binding Globulin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Thyroxine Binding Globulin (TBG) is one of three proteins responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3 triiodothyronine (T3) in the bloodstream, along with transthyretin and albumin. TBG has the highest affinity for T4 and T3, but is present in the lowest concentration of the three proteins. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 & T3, TBG is rarely more than 25% saturated with ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. Genomically, TBG is a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG is synthesized primarily in the liver.
Function:
Major thyroid hormone transport protein in serum.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed by the liver and secreted in plasma.
DISEASE:
Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.
Similarity:
Belongs to the serpin family.
Database links:Entrez Gene: 282518 Cow
Entrez Gene: 6906 Human
Entrez Gene: 397125 Pig
Omim: 314200 Human
SwissProt: Q9TT36 Cow
SwissProt: P05543 Human
SwissProt: Q9TT35 Pig
Unigene: 76838 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.