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货号： bs-4276R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4276R-AF555
- 英文名称
- Anti-ELAC2/HPC2/AF555
- 中文名称
- AF555标记的遗传性前列腺癌蛋白2抗体
- 别 名
- elaC homolog 2; ElaC homolog protein 2; ELC2; Heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z2; RNase Z2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z2; Zinc phosphodiesterase ELAC protein 2; RNZ2_HUMAN; Ribonuclease Z 2; RNase Z 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 染色质和核信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 92kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ELAC2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ELAC2 is a zinc phosphodiesterase which displays some tRNA 3 processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3 trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer.
Function:
Zinc phosphodiesterase, which displays mitochondrial tRNA 3-processing endonuclease activity. Involved in tRNA maturation, by removing a 3-trailer from precursor tRNA.
Subunit:
Homodimer. Interacts with PTCD1.
Subcellular Location:
Mitochondrion. Nucleus. Note=Mainly mitochondrial.
Tissue Specificity:
Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
Similarity:
Belongs to the RNase Z family.
Database links:Entrez Gene: 60528 Human
Entrez Gene: 68626 Mouse
Entrez Gene: 282826 Rat
Omim: 605367 Human
SwissProt: Q9BQ52 Human
SwissProt: Q80Y81 Mouse
SwissProt: Q8CGS5 Rat
Unigene: 434232 Human
Unigene: 157711 Mouse
Unigene: 163124 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.