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货号： bs-5748R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5748R-AF555
- 英文名称
- Anti-DBF4B/AF555
- 中文名称
- AF555标记的S期激酶活化蛋白DBF4B抗体
- 别 名
- Activator of S phase kinase like protein 1; ASK like protein 1; ASKL1; chifb; Chiffon homolog B; DBF 4B; DBF4 homolog B (S. cerevisiae); DBF4 homolog B; Dbf4 related factor 1; DRF1; Protein DBF4 homolog B; ZDBF1B; Zinc finger DBF type containing 1B; DBF4B_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 18kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DBF4B/ASKL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
DBF4B is a regulatory subunit for CDC7, a serine-threonine kinase which links cell cycle regulation to genome duplication. The complex CDC7-DBF4B selectively phosphorylates the MCM2 subunit at Ser-40 and then is involved in regulating the initiation of DNA replication during cell cycle. DBF4B localizes to the nucleus and its expression is cell cycle-regulated.
Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at Ser-40 and then is involved in regulating the initiation of DNA replication during cell cycle.
Subunit:
Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4/DBF4A or DBF4B. Such complexes are stable upon replication stress.
Subcellular Location:
Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
Tissue Specificity:
Widely expressed. Highly expressed in testis.
Post-translational modifications:
Phosphorylated.
Similarity:
Contains 1 BRCT domain.
Contains 1 DBF4-type zinc finger.
Database links:Entrez Gene: 80174 Human
Omim: 611661 Human
SwissProt: Q8NFT6 Human
Unigene: 369998 Human
Unigene: 728986 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.