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货号： bs-5765R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5765R-AF555
- 英文名称
- Anti-LANCL2/AF555
- 中文名称
- AF555标记的G蛋白偶联受体69B
- 别 名
- G protein coupled receptor 69B; LanC (bacterial lantibiotic synthetase component C) like 2; TASP; Testis specific adriamycin sensitivity protein; LANC2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 染色质和核信号 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LANCL2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LANCL2 belongs to the LanC like protein family. It is expressed in the brain and testis. LANCL2 is a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in 20% of all glioblastomas. Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin).
Function:
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Subunit:
Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.
Subcellular Location:
Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin).
Tissue Specificity:
Expressed in brain and testis.
Post-translational modifications:
Myristoylated. Essential for membrane association.
Similarity:
Belongs to the LanC-like protein family.
Database links:
UniProtKB/Swiss-Prot: Q9NS86.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.