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货号： bs-2928R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2928R-AF555
- 英文名称
- Anti-PDLIM3/AF555
- 中文名称
- AF555标记的辅肌动蛋白相关LIM蛋白抗体
- 别 名
- ALP; Actinin associated LIM protein; Actinin-associated LIM protein; Alpha actinin 2 associated LIM protein; Alpha-actinin-2-associated LIM protein; DKFZp686L0362; Enigma homolog; PDLI3_HUMAN; PDLIM 3; PDLIM-3; PDLIM3; PDZ and LIM domain 3; PDZ and LIM domain protein 3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PDLIM3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy.
Function:
May play a role in the organization of actin filament arrays within muscle cells.
Subunit:
Interacts with ACTN2.
Subcellular Location:
Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
Tissue Specificity:
Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
Similarity:
Contains 1 LIM zinc-binding domain.
Contains 1 PDZ (DHR) domain.
Database links:Entrez Gene: 538516 Cow
Entrez Gene: 27295 Human
Entrez Gene: 53318 Mouse
Entrez Gene: 114108 Rat
Omim: 605889 Human
SwissProt: Q3SYZ8 Cow
SwissProt: Q53GG5 Human
SwissProt: O70209 Mouse
SwissProt: Q66HS7 Rat
Unigene: 442702 Human
Unigene: 731826 Human
Unigene: 282900 Mouse
Unigene: 13361 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.