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货号： bs-5972R-AF555 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5972R-AF555
- 英文名称
- Anti-Ribonuclease 6/AF555
- 中文名称
- AF555标记的核糖核酸酶6抗体
- 别 名
- Ribonuclease T2; RNASE6PL; RP11 514O12.3; RNASET2; RNASE6PL; RNT2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RelB
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. There are 2 isoforms produced by alternative splicing.
Subcellular Location:
Secreted. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.
Tissue Specificity:
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
DISEASE:
Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.
Similarity:
Belongs to the RNase T2 family.
Database links:Entrez Gene: 8635 Human
Entrez Gene: 100037283 Mouse
Entrez Gene: 68195 Mouse
Entrez Gene: 292306 Rat
Omim: 612944 Human
SwissProt: O00584 Human
SwissProt: Q9CQ01 Mouse
Unigene: 529989 Human
Unigene: 181237 Mouse
Unigene: 426736 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.